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IA and IT interact to set first spike latency (Molineux et al 2005)
a_and_t [?]
Using patch clamp and modeling, we illustrate that spike latency characteristics are the product of an interplay between I(A) and low-threshold calcium current (I(T)) that requires a steady-state difference in the inactivation parameters of the currents. Furthermore, we show that the unique first-spike latency characteristics of stellate cells have important implications for the integration of coincident IPSPs and EPSPs, such that inhibition can shift first-spike latency to differentially modulate the probability of firing.
  • Neuron or other electrically excitable cell Show Other
  • Molineux ML, Fernandez FR, Mehaffey WH, Turner RW (2005) Show Other
Cerebellar stellate cell
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Revisions: 6
Last Time: 11/29/2005 4:23:34 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin