BrainPharm: Computational model - Dendritic Na inactivation drives a decrease in ISI (Fernandez et al 2005)

Computational model

Data

Name

Dendritic Na inactivation drives a decrease in ISI (Fernandez et al 2005)

Submitter name

Pipeline ID

Model File

na_excit [?]

Notes

We use a combination of dynamical analysis and electrophysiological recordings to demonstrate that spike broadening in dendrites is primarily caused by a cumulative inactivation of dendritic Na(+) current. We further show that a reduction in dendritic Na(+) current increases excitability by decreasing the interspike interval (ISI) and promoting burst firing.

Model Neurons

More Cells

ELL pyramidal cell Show Other

Model Currents

I Na,t Show Other
I K Show Other

Model Receptors

Model Type

Neuron or other electrically excitable cell Show Other

Model Concept

Activity Patterns Show Other
Dendritic Action Potentials Show Other
Active Dendrites Show Other

Simulator software

MATLAB Show Other

Model papers

Fernandez FR, Mehaffey WH, Turner RW (2005) Show Other

Gene

hg folder name (applicable when in ModelDB hg)

Region Organism

Model ID Number

Gap Junctions

Implemented by

Fernandez FR [ffernand at ucalgary.ca] Show Other
Mehaffey WH Show Other

Public Submitter Email Address

Other Neuron

ELL pyramidal neurons

Model Neurotransmitters

Other Receptor

Other Current

Other Neurotransmitter

Other Model Type

Other Concept

Other Simulator

Other Implementer

Alternative Version

Citation

Default File Notes

Other Gene

Simulation Platform ID

Has Model View

False

Component

RAM

Hide Auto-launch button

False

Run Protocols

ICG Channel Details

Species

Other categories referring to Dendritic Na inactivation drives a decrease in ISI (Fernandez et al 2005)

Revisions:	14
Last Time:	4/13/2007 4:01:13 PM
Reviewer:	Tom Morse - MoldelDB admin
Owner:	Tom Morse - MoldelDB admin