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Data
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Inhibitory control by an integral feedback signal in prefrontal cortex (Miller and Wang 2006)
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The prefrontal cortex (PFC) is known to be critical for inhibitory
control of behavior, but the underlying mechanisms are unclear.
Here, we propose that inhibitory control can be instantiated by an
integral signal derived from working memory, another key function of the PFC. Specifically, we assume that an integrator converts
excitatory input into a graded mnemonic activity that provides an
inhibitory signal (integral feedback control) to upstream afferent
neurons. We demonstrate this scenario in a neuronal-network
model for a temporal discrimination task... See paper for details
and more.
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Miller, Paul [pmiller at brandeis.edu] Show
Other
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