Computational model
A model for pituitary GH(3) lactotroph (Wu and Chang 2005)
GH3_Katp [?]
The ATP-sensitive K(+) (K(ATP)) channels are composed of sulfonylurea receptor and inwardly rectifying K(+) channel (Kir6.2) subunit. These channels are regulated by intracellular ADP/ATP ratio and play a role in cellular metabolism. ... The objective of this study was to determine whether Diethyl pyrocarbonate (DEPC) modifies K(ATP)-channel activity in pituitary GH(3) cells. ... Simulation studies also demonstrated that the increased conductance of K(ATP)-channels used to mimic DEPC actions reduced the frequency of spontaneous action potentials and fluctuation of intracellular Ca(2+). The results indicate that chemical modification with DEPC enhances K(ATP)-channel activity and influences functional activities of pituitary GH(3) cells. See paper for more and details.
  • Neuron or other electrically excitable cell Show Other
Pituitary cell
Sheng-Nan Wu, Han-Dong Chang
Other categories referring to A model for pituitary GH(3) lactotroph (Wu and Chang 2005)
Revisions: 16
Last Time: 7/26/2015 11:25:08 AM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin