|
|
|
Data
|
Tonic firing in substantia gelatinosa neurons (Melnick et al 2004)
|
|
|
|
|
|
|
Ionic conductances underlying excitability in tonically firing neurons
(TFNs) from substantia gelatinosa (SG) were studied by the patch-clamp
method in rat spinal cord slices. ... Suppression of Ca2+ and KCA currents ... did not
abolish the basic pattern of tonic firing, indicating that it was
generated by voltage-gated Na+ and K+ currents. ...
on the basis of present data, we created a model of TFN
and showed that Na+ and KDR currents are sufficient to generate a
basic pattern of tonic firing. It is concluded that the balanced
contribution of all ionic conductances described here is important for
generation and modulation of tonic firing in SG neurons. See paper for more and details.
|
|
|
|
|
|
|
|
|
-
Neuron or other electrically excitable cell Show
Other
|
|
|
|
|
-
Melnick IV, Santos SF, Szokol K, Szûcs P, Safronov BV (2004) Show
Other
|
|
|
b
|
|
|
|
|
|
|
-
Safronov, Boris [safronov at ibmc.up.pt] Show
Other
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
