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Data
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Cardiac action potential based on Luo-Rudy phase 1 model (Luo and Rudy 1991), (Wu 2004)
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A mathematical model of the membrane action potential of the mammalian
ventricular cell is introduced. The model is based, whenever possible,
on recent single-cell and single-channel data and incorporates the
possibility of changing extracellular potassium concentration [K]o. The
fast sodium current, INa, is characterized by fast upstroke velocity (Vmax
= 400 V/sec) and slow recovery from inactivation. The time-independent
potassium current, IK1, includes a negative-slope phase and displays
significant crossover phenomenon as [K]o is varied. The time-dependent
potassium current, IK, shows only a minimal degree of crossover. A novel
potassium current that activates at plateau potentials is included in
the model. The simulated action potential duplicates the experimentally
observed effects of changes in [K]o on action potential duration and rest
potential. See papers for more and details.
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snwu
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Drs. Sheng-Nan Wu and Ruey J Sung
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