Pathological mechanism
beta-amyloid reduces IA
Bicuculline and DNQX used to silent synapses
  • Dendritic Hypothesis - K+ current Show Other
  • Hippocampus CA1 pyramidal GLU cell Show Other
  • beta-Amyloid increases dendritic Ca2+ influx by inhibiting the A-type K+ current in hippocampal CA1 pyramidal neurons. Show Other
Application of beta-amyloid to outside-out patches reduces the A-current; leading to increased dendritic calcium influx and loss of calcium homeostasis, potentially causing synaptic failure and initiating neuronal degenerative proceses(Chen C 2005). The concentration of aBeta used in Chen's experiments are much higher than the levels observed in vivo. There is a possibility that aBeta may have local concentrations as high as the values used in these experiments, however that is speculation.
  • Soluble Aß affects CA1 Hippocampal neurons by action on A-type channels Show Other
  • A-type K+ channel block causes increased back-propagation of action potentials Show Other
  • Aß influences neuronal excitability by effects on dendritic ion channels Show Other
Other categories referring to beta-amyloid reduces IA
Revisions: 17
Last Time: 4/19/2018 5:36:20 PM
Reviewer: System Administrator
Owner: System Administrator