Pathological mechanism

Data

Name beta-amyloid reduces IA

Description Bicuculline and DNQX used to silent synapses

Hypothesis Dendritic Hypothesis - K+ current Show Other

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element

Pathological action Inhibits Show Other

Process

Process action

Transmitter(s)

Receptor(s)

Channel(s) I A Show Other

Pharmacological Agent

Pharmacological Action

Brain region Hippocampus CA1 Show Other

Neuron Hippocampus CA1 pyramidal GLU cell Show Other

Cell model

Cellular compartment Soma Show Other Dendrite Show Other

PubMed ID 16289381

Citation beta-Amyloid increases dendritic Ca2+ influx by inhibiting the A-type K+ current in hippocampal CA1 pyramidal neurons. Show Other

AlzWeb

Notes Application of beta-amyloid to outside-out patches reduces the A-current; leading to increased dendritic calcium influx and loss of calcium homeostasis, potentially causing synaptic failure and initiating neuronal degenerative proceses(Chen C 2005). The concentration of aBeta used in Chen's experiments are much higher than the levels observed in vivo. There is a possibility that aBeta may have local concentrations as high as the values used in these experiments, however that is speculation.

Pathology Alzheimer Show Other

Stage Early Show Other

Question

Claim Soluble Aß affects CA1 Hippocampal neurons by action on A-type channels Show Other A-type K+ channel block causes increased back-propagation of action potentials Show Other Aß influences neuronal excitability by effects on dendritic ion channels Show Other