Pathological mechanism

Data

Name Model block of I_A

Description

Hypothesis Dendritic Hypothesis - K+ current Show Other

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element

Pathological action Inhibits Show Other

Process

Process action

Transmitter(s)

Receptor(s)

Channel(s) I A Show Other

Pharmacological Agent

Pharmacological Action

Brain region Hippocampus CA1 Show Other

Neuron Hippocampus CA1 pyramidal GLU cell Show Other

Cell model

Cellular compartment General or unspecified Show Other

PubMed ID 8986775

Citation Effect of beta-amyloid block of the fast-inactivating K+ channel on intracellular Ca2+ and excitability in a modeled neuron. Show Other

AlzWeb

Notes A model shows that block of I_A is sufficient to cause membrane depolarization, calcium influx, and increased excitability (Good TA, Murphy RM 1996). The increased excitability is in the opposite direction of aBeta's usual effect on neurons which is to make them less excitable.

Pathology Alzheimer Show Other

Stage Early Show Other

Question

Claim