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Pathological mechanism
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Model block of I_A
  • Dendritic Hypothesis - K+ current Show Other
  • Effect of beta-amyloid block of the fast-inactivating K+ channel on intracellular Ca2+ and excitability in a modeled neuron. Show Other
A model shows that block of I_A is sufficient to cause membrane depolarization, calcium influx, and increased excitability (Good TA, Murphy RM 1996). The increased excitability is in the opposite direction of aBeta's usual effect on neurons which is to make them less excitable.
Other categories referring to Model block of I_A
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Last Time: 4/19/2018 5:32:18 PM
Reviewer: System Administrator
Owner: System Administrator