Pathological mechanism

Data

Name beta-Amyloid impairs LTP/LTD

Description

Hypothesis LTP hypothesis Show Other

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element

Pathological action Inhibits Show Other

Process LTP Show Other

Process action independent of Show Other

Transmitter(s)

Receptor(s) NMDA Show Other

Channel(s) I Calcium Show Other

Pharmacological Agent

Pharmacological Action

Brain region Hippocampus CA1 Show Other

Neuron Hippocampus CA1 pyramidal GLU cell Show Other

Cell model

Cellular compartment Dendrite Show Other

PubMed ID 16154266

Citation Mechanism of impairment of long-term potentiation by amyloid beta is independent of NMDA receptors or voltage-dependent calcium channels in hippocampal CA1 pyramidal neurons. Show Other

AlzWeb

Notes Impairment of LTP by beta-Amyloid is independent of NMDA receptors or voltage dependent Ca currents (Nomura I et al. 2005)

Pathology Alzheimer Show Other

Stage

Question

Claim