Pathological mechanism

Data

Name AMPA receptor downscaling in AD

Description

Hypothesis LTP hypothesis Show Other

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element

Pathological action Inhibits Show Other

Process

Process action

Transmitter(s)

Receptor(s) AMPA Show Other

Channel(s)

Pharmacological Agent

Pharmacological Action

Brain region Hippocampus CA1 Show Other

Neuron

Cell model

Cellular compartment

PubMed ID 16492745

Citation AMPA receptor downscaling at the onset of Alzheimer's disease pathology in double knockin mice. Show Other

AlzWeb

Notes Experiments with double knockin mice suggest that AMPARs are important synaptic targets for AD and provide evidence that cognitive impairment may involve downscaling of postsynaptic AMPAR function (Chang EH et al. 2006)

Pathology Alzheimer Show Other

Stage Early Show Other

Question

Claim