Pathological mechanism

Data

Name beta-Amyloid activates I_L by MAP Kinase

Description

Hypothesis Dendritic Hypothesis - Ca++ currents Show Other

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element MAP Kinase Show Other

Pathological action

Process

Process action Activates Show Other

Transmitter(s)

Receptor(s)

Channel(s) I L high threshold Show Other

Pharmacological Agent

Pharmacological Action

Brain region

Neuron

Cell model Oocyte Show Other

Cellular compartment

PubMed ID 10514528

Citation Activation of the L voltage-sensitive calcium channel by mitogen-activated protein (MAP) kinase following exposure of neuronal cells to beta-amyloid. MAP kinase mediates beta-amyloid-induced neurodegeneration. Show Other

AlzWeb

Notes "(Our experimental) findings indicate that redirection rather than increased activation of MAP-Kinase activity mediates beta_Amyloid-induced neurotoxicity." (Ekinci FJ et al. 1999).

Pathology Alzheimer Show Other

Stage Early Show Other

Question Exclude - Neurotoxicity

Claim