Pathological mechanism

Data

Name beta-Amyloid-induced depression of LTP attenuated by Verapamil

Description

Hypothesis LTP hypothesis Show Other

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element

Pathological action Reduces Show Other

Process LTP Show Other

Process action Activates Show Other

Transmitter(s)

Receptor(s)

Channel(s) I L high threshold Show Other

Pharmacological Agent Verapamil Show Other

Pharmacological Action Blocks Show Other

Brain region Hippocampus CA1 Show Other

Neuron

Cell model

Cellular compartment

PubMed ID 12611943

Citation A beta 25-35-induced depression of long-term potentiation in area CA1 in vivo and in vitro is attenuated by verapamil. Show Other

AlzWeb

Notes Experimental findings suggest that verapamil, an L-type (VDCC) calcium channel blocker may be useful in the cognitive deficits associated with AD (Freir DB et al. 2003)

Pathology Alzheimer Show Other

Stage Early Show Other

Question

Claim