|
|
|
Data
|
CA1 pyramidal cell: I_NaP and I_M contributions to somatic bursting (Golomb et al 2006)
|
|
|
|
|
|
|
To study the mechanisms of bursting, we have constructed a
conductance-based, one-compartment model of CA1 pyramidal neurons. In this neuron model,
reduced [Ca2+]o is simulated by negatively shifting the activation curve of the persistent Na+ current
(INaP), as indicated by recent experimental results. The neuron model accounts, with different
parameter sets, for the diversity of firing patterns observed experimentally in both zero and normal
[Ca2+]o. Increasing INaP in the neuron model induces bursting and increases the number of spikes
within a burst, but is neither necessary nor sufficient for bursting. We show, using fast-slow analysis
and bifurcation theory, that the M-type K+ current (IM) allows bursting by shifting neuronal behavior
between a silent and a tonically-active state, provided the kinetics of the spike generating currents are
sufficiently, though not extremely, fast. We suggest that bursting in CA1 pyramidal cells can be
explained by a single compartment *square bursting* mechanism with one slow variable, the
activation of IM. See paper for more and details.
|
-
Hippocampus CA1 pyramidal GLU cell Show
Other
|
|
|
|
|
|
|
-
Neuron or other electrically excitable cell Show
Other
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
-
Golomb, David [golomb at bgu.ac.il] Show
Other
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
