Pathological mechanism

Data

Name Aluminum alters GABAA receptors

Description

Hypothesis

Extracelular pathological element Aluminum Show Other

Intracelular pathological element

Pathological action Potentiates Show Other

Process Cognitive Decline in Alzheimer's Show Other

Process action Alters Show Other

Transmitter(s)

Receptor(s) GabaA Show Other

Channel(s)

Pharmacological Agent

Pharmacological Action

Brain region Olfactory Bulb main Show Other

Neuron Olfactory bulb main mitral GLU cell Show Other

Cell model

Cellular compartment Soma Show Other Dendrite Show Other

PubMed ID 9705466

Citation Selective modulation of GABAA receptors by aluminum. Show Other

AlzWeb

Notes " ... aluminum can alter the function of GABAA receptors and may suggest that aluminum can contribute to cognitive impairment through disruption of inhibitory circuits." (Trombley PQ 1998)

Pathology

Stage Early Show Other

Question

Claim