Pathological mechanism

Data

Name Abeta modulates A current (HEK293 cells)

Description

Hypothesis Dendritic Hypothesis - K+ current Show Other

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element

Pathological action Modulates Show Other

Process

Process action

Transmitter(s)

Receptor(s)

Channel(s) I Potassium Show Other

Pharmacological Agent

Pharmacological Action

Brain region

Neuron

Cell model

Cellular compartment

PubMed ID 16271805

Citation Amyloid beta peptide as a physiological modulator of neuronal 'A'-type K(+) current. Show Other

AlzWeb

Notes "Control of neuronal spiking patterns resides, in part, in the type and degree of expression of voltage-gated K(+) channel subunits. Abeta is a modulator of Kv4 subunit expression in neurones at both the functional and the molecular level. Thus Abeta is not only involved in Alzheimer pathology, but is also an important physiological regulator of ion channel expression and hence neuronal excitability." (Plant LD et al. 2005)

Pathology Alzheimer Show Other

Stage Early Show Other

Question

Claim Blockage of the hyperpolarizing A-type K+ channels makes the dendrites more excitable Show Other A-type K+ channel block makes dendrites more excitable Show Other