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Pathological mechanism
  Data
Postsynaptic calcium concentration in aging neurons is closely associated with altered plasticity.
  • Dendritic Hypothesis - Ca++ currents Show Other
... the selective L-VSCC (L-type volt. sens. Ca chan.) agonist Bay K8644 increased the afterhyperpolarization and mimicked the depressive effects of aging on FF (frequency facilititation) in young-adult neurons. Thus, during physiologically relevant firing patterns in aging neurons, postsynaptic Ca(2+) elevation is closely associated with altered neuronal plasticity. Moreover, selectively increasing postsynaptic L-VSCC activity, as occurs in aging, negatively regulated a form of short-term plasticity that enhances synaptic throughput. Together, the results elucidate novel processes that may contribute to impaired cognitive function in aging (Thibault O, et al. 2001).
Exclude - No pathology
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Revisions: 6
Last Time: 10/27/2017 9:49:21 PM
Reviewer: System Administrator
Owner: Tom Morse