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Neostriatum interneuron ACh cell
Wilson, CJ, in Synaptic Organization of the Brain, 4th ed. (Shepherd, GM, ed.) New York: Oxford University Press 1998.
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 Neuronal Receptors (15)
  
SN Property present CF-Compartment Receptor Connect Note Publication facts
1 Yes Axon terminal Glutamate The mGluRs belonging to group I and II are located on the axon terminals of striatal cholinergic interneurons, their activation resulting in facilitation and inhibition, respectively, of acetylcholine release
2 Yes Soma Glycine Strychnine-sensitive glycine receptors are present on a subpopulation of the cholinergic interneurons in rat caudatoputamen, supporting the hypothesis that (excitatory) glycine receptors inducing striatal release of [(3)H]acetylcholine may be localized to cholinergic neurons
3 Yes Distal equivalent dendrite D1 Prolongation of ISI through a D1 dopamine receptor-mediated enhancement of the afterhyperpolarization (AHP)
4 Yes Distal equivalent dendrite AMPA At least 40% of choline acetyltransferase-immunopositive cholinergic interneurons were immunopositive for GluR1 or GluR4
5 Yes Distal equivalent dendrite GabaA During periods of induced regular firing, intrastriatal stimuli were used to evoke pharmacologically isolated monosynaptic AMPA receptor-mediated EPSPs or GABAA receptor-mediated IPSPs. EPSPs evoked during the interspike interval (ISI) produced a phase-dependent decrease in the ISI, whereas IPSPs produced a phase-independent prolongation of the ISI
6 Yes Proximal equivalent dendrite Muscarinic Intrastriatal stimulation-induced release of ACh from presynaptic nerves hyperpolarizes cholinergic interneurons by activating muscarinic receptors (probably M2) located on somatodendritic region
7 Yes Soma Muscarinic Intrastriatal stimulation-induced release of ACh from presynaptic nerves hyperpolarizes cholinergic interneurons by activating muscarinic receptors (probably M2) located on somatodendritic region
8 Yes Distal equivalent dendrite D2 D2 dopamine receptors reduce N-type Ca2+ currents in rat neostriatal cholinergic interneurons
9 Yes Distal equivalent dendrite Dopaminergic Receptor Achergic neurons are in direct synaptic contact with dopaminergic axons in the rat neostriatum
10 Yes Proximal equivalent dendrite mGluR2
11 Yes Middle equivalent dendrite mGluR1
12 Yes Middle equivalent dendrite mGluR2
13 Yes Distal equivalent dendrite mGluR2
14 Yes Distal equivalent dendrite mGluR1
15 Yes Proximal equivalent dendrite mGluR1
 Neuronal Currents (11)
  
SN Property present CF-Compartment Current Connect Note Publication facts
1 Yes Soma I h Spontaneous firing was driven by the combined action of a sodium current and the hyperpolarization-activated cation current (I(h)), which together ensured that there was no zero current point in the subthreshold voltage range. Spike-triggered calcium entry shaped the falling phase of the action potential waveform and activated calcium-dependent potassium channels
2 Yes Soma I Calcium Spike-triggered calcium entry shaped the falling phase of the action potential waveform and activated calcium-dependent potassium channels
3 Yes Soma I K,Ca Spontaneous firing was driven by the combined action of a sodium current and the hyperpolarization-activated cation current (I(h)), which together ensured that there was no zero current point in the subthreshold voltage range. Spike-triggered calcium entry shaped the falling phase of the action potential waveform and activated calcium-dependent potassium channels
4 Yes Soma I Na,p Spontaneous firing was driven by the combined action of a sodium current and the hyperpolarization-activated cation current (I(h)), which together ensured that there was no zero current point in the subthreshold voltage range. Spike-triggered calcium entry shaped the falling phase of the action potential waveform and activated calcium-dependent potassium channels
5 Yes Soma I Potassium Cholinergic interneurones in rat exhibit a ATP-sensitive potassium channel current. sigle-cell-RT-PCR shows that this channel is formed from Kir6.1 and SUR1 subunits
6 Yes Soma I A Presence of Kv4.2 but not Kv1.4 subunits in the somatodendritic membrane. Depolarization-activated potassium currents in cholinergic interneurons were dominated by a rapidly inactivating, K+-selective A current that became active at subthreshold potentials.
7 Yes Distal equivalent dendrite I A Presence of Kv4.2 but not Kv1.4 subunits in the somatodendritic membrane. Depolarization-activated potassium currents in cholinergic interneurons were dominated by a rapidly inactivating, K+-selective A current that became active at subthreshold potentials
8 Yes Middle equivalent dendrite I A Presence of Kv4.2 but not Kv1.4 subunits in the somatodendritic membrane. Depolarization-activated potassium currents in cholinergic interneurons were dominated by a rapidly inactivating, K+-selective A current that became active at subthreshold potentials
9 Yes Proximal equivalent dendrite I A Presence of Kv4.2 but not Kv1.4 subunits in the somatodendritic membrane. Depolarization-activated potassium currents in cholinergic interneurons were dominated by a rapidly inactivating, K+-selective A current that became active at subthreshold potentials
10 Yes Soma I N N-type Ca2+ currents in rat neostriatal cholinergic interneurons is reduced through D2 receptor activity
11 Yes Soma I L high threshold Evidence of presence of high-threshold calcium channel
 Neuronal Transmitters (1)
  
SN Property present CF-Compartment transmitter Connect Note Publication facts
1 Yes Axon terminal Acetylcholine onto fast-spiking interneurons Ach exerted two distinct effects on fast-spiking interneurons: Ach directly depolarized FS interneurons by acting on nondesensitizing soma-dendritic nicotinic receptors. In addition, Ach attenuated the GABAergic inhibition of projection neurons by fast-spiking interneurons through activation of presynaptic muscarinic receptors
Other categories referring to Neostriatum interneuron ACh cell
Computational model.Model Neurons   (1)
Interneurons Connectivity.Interneuron   (1)
2 Objects Relationship (edge).Object Two (target)   (1)
Neuronal Structure.Neurons   (1)
Revisions: 12
Last Time: 6/19/2019 12:25:00 PM
Reviewer: System Administrator
Owner: Buqing Mao