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Cerebellum interneuron granule cell
Modified from Llinas, RR and Walton, KD in Synaptic Organization of the Brain, 4th ed. (Shepherd, GM., ed.). New York: Oxford University Press 1998.
21
 Neuronal Receptors (7)
  
SN Property present CF-Compartment Receptor Connect Note Publication facts
1 Yes Distal equivalent dendrite AMPA AMPA receptors during development: granule cells express a heterogeneous population of AMPA receptors, a subset of which are segregated to postsynaptic sites after synaptogenesis >412<
2 Yes Distal equivalent dendrite NMDA from extrinsic and intrinsic mossy fibers Silent synapses during development >413<
3 Yes Axon terminal GabaB GABA spillover Whereas, activation of the adenosine A1 receptor reduces synaptic strength by modulating presynaptic calcium channels, baclofen modulates presynaptic calcium channels as well, but also affects release processes downstream from calcium entry >415<
4 Yes Soma Nicotinic mossy fiber-granule cell synapse In slices that preserve mossy-fiber to granule cell synapses, Ach induced diverse responses in granule cells, one response being somatic current (nAChR also mediated postsynaptic currents, PSCs, which, however, were glutamatergic in nature, indicating a presynaptic mechanism. ) >417<
5 Yes Soma GabaA Granule cells compensate for the lack GABAA receptors (in somatic location? ) by expressing the two-pore-domain K+ channel TASK-1, a voltage-independent K + conductance so as to maintain normal neuronal behaviour; this finding highlight the importance of GABAA receptor-mediated background inhibition >418<
6 Yes Axon terminal NMDA NMDA reversibly depresses postsynaptic currents, through a trans-synaptic mechanism that involves release from parallel fibers nitric oxide that decreases the glutamate sensitivity of the Purkinje cell >422<
7 Yes Axon terminal Glutamate Activation of mGluR1 in Purkinje cells causes a Ca-dependent release of a retrograde messenger, probably Glutamate, which acts on presynaptic ionotropic glutamatergic receptor (AMPA/kinate) on the parallel fibers (PFs), depolarizes PFs and modulates neurotransmission from parellel fibers to Purkinje cells >421<
 Neuronal Currents (4)
  
SN Property present CF-Compartment Current Connect Note Publication facts
1 Yes Axon terminal I Calcium Calcium is involved in delayed release of neurotransmitter at synapses between granule cell their postsynaptic targets (stellate cells and Purkinje cells) >416<
2 Yes Soma I Potassium Single-channel and whole-cell recording identified three types of current: a transient inward sodium current and a transient and a sustained outward potassium current >429<
3 Yes Soma I A Presence of Subthreshold-operating transient (A-type) K(+) currents (I(SA)s), as indicated by an accesspry subunit that accelerates the kinetics of this current >428<
4 Yes Soma I Na,t Single-channel and whole-cell recording identified three types of current: a transient inward sodium current and a transient and a sustained outward potassium current >429<
 Neuronal Transmitters (2)
  
SN Property present CF-Compartment transmitter Connect Note Publication facts
1 Yes Axon terminal NO At parallel fiber (PF) -Purkinje cell synapses, NMDA reversibly depresses postsynaptic currents, through a trans-synaptic mechanism that involves release from PFs nitric oxide that decreases the glutamate sensitivity of the Purkinje cell >422<
2 Yes Axon terminal Glutamate parallel fibers to Purkinje cells >223<
Other categories referring to Cerebellum interneuron granule cell
Computational model.Model Neurons   (17)
Interneurons Connectivity.Interneuron   (1)
Pathological mechanism.Neuron   (1)
2 Objects Relationship (edge).Object Two (target)   (1)
Neuronal Structure.Neurons   (1)
Revisions: 9
Last Time: 12/18/2015 2:51:52 PM
Reviewer: Luis Marenco
Owner: Buqing Mao