SenseLab
Neuron
  Data
Cerebellum interneuron granule cell
Modified from Llinas, RR and Walton, KD in Synaptic Organization of the Brain, 4th ed. (Shepherd, GM., ed.). New York: Oxford University Press 1998.
21
 Neuronal Receptors (7)
  
SN Property present CF-Compartment Receptor Connect Note References Notes Publication facts
1 Yes Distal equivalent dendrite AMPA AMPA receptors during development: granule cells express a heterogeneous population of AMPA receptors, a subset of which are segregated to postsynaptic sites after synaptogenesis (>412<). AMPA receptors during development: granule cells express a heterogeneous population of AMPA receptors, a subset of which are segregated to postsynaptic sites after synaptogenesis >412<
2 Yes Distal equivalent dendrite NMDA from extrinsic and intrinsic mossy fibers Potentiation of intrinsic excitability was induced by relatively weaker inputs than those that induce potentiation of synaptic efficacy; NMDA receptors are involved in both aspects of potentiation (>411<). The NMDA responses of two types of feedforward excitatory interneurons in the granular layer, the granule cell and unipolar brush cell (UBC), were compared. A subset of granule cells receive influence from UBC via extrinsic mossy fibers (>405<) Silent synapses during development (>413<). Silent synapses during development >413<
3 Yes Axon terminal GabaB GABA spillover Modulation of synaptic transmission between granule cells and Purkinje cells via presynaptic GABAB receptors (>414<). Whereas, activation of the adenosine A1 receptor reduces synaptic strength by modulating presynaptic calcium channels, baclofen modulates presynaptic calcium channels as well, but also affects release processes downstream from calcium entry (>415<). Whereas, activation of the adenosine A1 receptor reduces synaptic strength by modulating presynaptic calcium channels, baclofen modulates presynaptic calcium channels as well, but also affects release processes downstream from calcium entry >415<
4 Yes Soma Nicotinic mossy fiber-granule cell synapse In slices that preserve mossy-fiber to granule cell synapses, Ach induced diverse responses in granule cells, one response being somatic current (nAChR also mediated postsynaptic currents, PSCs, which, however, were glutamatergic in nature, indicating a presynaptic mechanism. ) (>417<) In slices that preserve mossy-fiber to granule cell synapses, Ach induced diverse responses in granule cells, one response being somatic current (nAChR also mediated postsynaptic currents, PSCs, which, however, were glutamatergic in nature, indicating a presynaptic mechanism. ) >417<
5 Yes Soma GabaA Granule cells compensate for the lack GABAA receptors (in somatic location? ) by expressing the two-pore-domain K+ channel TASK-1, a voltage-independent K + conductance so as to maintain normal neuronal behaviour; this finding highlight the importance of GABAA receptor-mediated background inhibition (>418<). Granule cells compensate for the lack GABAA receptors (in somatic location? ) by expressing the two-pore-domain K+ channel TASK-1, a voltage-independent K + conductance so as to maintain normal neuronal behaviour; this finding highlight the importance of GABAA receptor-mediated background inhibition >418<
6 Yes Axon terminal NMDA Involvement of presynaptic NMDA receptors in cerebellar long-term depression at parallel fiber-Purkinje cell synapses (>420<). NMDA reversibly depresses postsynaptic currents, through a trans-synaptic mechanism that involves release from parallel fibers nitric oxide that decreases the glutamate sensitivity of the Purkinje cell (>422<). NMDA reversibly depresses postsynaptic currents, through a trans-synaptic mechanism that involves release from parallel fibers nitric oxide that decreases the glutamate sensitivity of the Purkinje cell >422<
7 Yes Axon terminal Glutamate Activation of mGluR1 in Purkinje cells causes a Ca-dependent release of a retrograde messenger, probably Glutamate, which acts on presynaptic ionotropic glutamatergic receptor (AMPA/kinate) on the parallel fibers (PFs), depolarizes PFs and modulates neurotransmission from parellel fibers to Purkinje cells (>421<). Activation of mGluR1 in Purkinje cells causes a Ca-dependent release of a retrograde messenger, probably Glutamate, which acts on presynaptic ionotropic glutamatergic receptor (AMPA/kinate) on the parallel fibers (PFs), depolarizes PFs and modulates neurotransmission from parellel fibers to Purkinje cells >421<
 Neuronal Currents (4)
  
SN Property present CF-Compartment Current Connect Note References Notes Publication facts
1 Yes Axon terminal I Calcium Potassium-induced glutamate release from granule cells is dependent on the entry of Ca++ through multiple types of Ca-channel including N-, L-, P/Q-types; a number of these channel subtypes seems to be involved in the presynaptic modulation, by GABAB receptors, of potassium-induced glutamate release (>427<). Activation of the adenosine A1 receptor reduces synaptic strength by modulating presynaptic calcium channels. Baclofen modulates presynaptic calcium channels as well but also affects release processes downstream from calcium entry (>415<). Calcium is involved in delayed release of neurotransmitter at synapses between granule cell their postsynaptic targets (stellate cells and Purkinje cells) (>416<). Calcium is involved in delayed release of neurotransmitter at synapses between granule cell their postsynaptic targets (stellate cells and Purkinje cells) >416<
2 Yes Soma I Potassium Granule cells that lack GABAA receptors (in somatic location? ) express the two-pore-domain K+ channel TASK-1, a voltage-independent K + conductance, so as to maintain normal neuronal behaviour (>418<). Importance for membrane excitability of an GABAB receptor-activated inward-rectifying potassium current, sensitive to pertussis toxin and barium (>419<). Cerebellar granule cells from young rats (postnatal days 1-9) possess voltage-activated inward Na+ current as well as two types of K+ current, IA and IK (>430<). Single-channel and whole-cell recording identified three types of current: a transient inward sodium current and a transient and a sustained outward potassium current (>429<). Single-channel and whole-cell recording identified three types of current: a transient inward sodium current and a transient and a sustained outward potassium current >429<
3 Yes Soma I A Cerebellar granule cells from young rats (postnatal days 1-9) possess voltage-activated inward Na+ current as well as two types of K+ current, IA and IK (>430<). Single-channel and whole-cell recording identified three types of current: a transient inward sodium current and a transient and a sustained outward potassium current (>429<) Presence of Subthreshold-operating transient (A-type) K(+) currents (I(SA)s), as indicated by an accesspry subunit that accelerates the kinetics of this current (>428<). Presence of Subthreshold-operating transient (A-type) K(+) currents (I(SA)s), as indicated by an accesspry subunit that accelerates the kinetics of this current >428<
4 Yes Soma I Na,t Cerebellar granule cells from young rats (postnatal days 1-9) possess voltage-activated inward Na+ current as well as two types of K+ current, IA and IK (>430<). Single-channel and whole-cell recording identified three types of current: a transient inward sodium current and a transient and a sustained outward potassium current (>429<). Nav1.6 is present in Cerebellar Granule Cells (>612<) Single-channel and whole-cell recording identified three types of current: a transient inward sodium current and a transient and a sustained outward potassium current >429<
 Neuronal Transmitters (2)
  
SN Property present CF-Compartment transmitter Connect Note References Notes Publication facts
1 Yes Axon terminal NO At parallel fiber (PF) -Purkinje cell synapses, NMDA reversibly depresses postsynaptic currents, through a trans-synaptic mechanism that involves release from PFs nitric oxide that decreases the glutamate sensitivity of the Purkinje cell (>422<). At parallel fiber (PF) -Purkinje cell synapses, NMDA reversibly depresses postsynaptic currents, through a trans-synaptic mechanism that involves release from PFs nitric oxide that decreases the glutamate sensitivity of the Purkinje cell >422<
2 Yes Axon terminal Glutamate parallel fibers to Purkinje cells Immunochemical evidence of glutamate as neurotransmitter in the terminals of parallel fibers (>426<). Glutamate release from parallel fibers (of granule cells) activates AMPA, mGluR on Purkinje cells (>425<) (>424<)(>223<). >223<
Other categories referring to Cerebellum interneuron granule cell
Computational model.Model Neurons   (17)
Interneurons Connectivity.Interneuron   (1)
Pathological mechanism.Neuron   (1)
2 Objects Relationship (edge).Object Two (target)   (1)
Neuronal Structure.Neurons   (1)
Revisions: 9
Last Time: 12/18/2015 2:51:52 PM
Reviewer: Luis Marenco
Owner: Buqing Mao