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Pathological mechanism
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Okadaic acid mediates tau phosphorylation via L channel activation
  • Dendritic Hypothesis - Ca++ currents Show Other
  • SH-SY-5Y human neuroblastoma cells Show Other
  • Okadaic acid mediates tau phosphorylation via sustained activation of the L-voltage-sensitive calcium channel. Show Other
Prior studies indicate that one of the kinases that phosphorylates tau (mitogen-activated protein kinase, or MAP kinase) does so at least in part indirectly within intact neuronal cells by phosphorylating and activating the L-voltage-sensitive calcium channel. Resultant calcium influx then fosters tau phosphorylation via one or more calcium-activated kinases. okadaic acid (OA) similarly may increase tau phosphorylation via sustained activation of the L-voltage-sensitive calcium channel. OA increased phospho-tau as indicated by increased immunoreactivity towards an antibody (PHF-1) directed against paired helical filaments from AD brain. This increase was blocked by co-treatment with the channel antagonist nimodipine. ... Okadaic acid (OA) treatment increased channel phosphorylation. The increases in calcium influx, PHF-1 immunoreactivity and channel phosphorylation were all attenuated by co-treatment with PD98059, which inhibits MAP kinase activity, suggesting that OA mediates these effects at least in part via sustained activation of MAP kinase. (Ekinci FJ et al. 2003)
  • Aß causes increased Ca++ influx by activation of L-type Ca++ channels Show Other
Other categories referring to Okadaic acid mediates tau phosphorylation via L channel activation
Revisions: 11
Last Time: 11/21/2008 10:18:59 AM
Reviewer: Pradeep Mutalik
Owner: Tom Morse