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Pathological mechanism
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p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro
  • Dendritic Hypothesis - Ca++ currents Show Other
  • p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro. Show Other
"p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro. ... Results show that sAbeta(1-42) at relatively low levels (1-5 microM) dose-dependently increases tau phosphorylation at AD-specific phosphoepitopes in differentiated N2a/p35 cells compared with controls, an effect that is blocked by antisense oligonucleotides against p35. sAbeta(1-42)-induced tau phosphorylation is concomitant with an increase in both p25 to p35 ratio and Cdk5 activity (but not protein levels). Additionally, blockade of L-type calcium channels or inhibition of calpain completely abolishes this effect." (Town et al. 2002)
  • Aß causes increased Ca++ influx by activation of L-type Ca++ channels Show Other
Other categories referring to p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro
Revisions: 12
Last Time: 11/21/2008 12:23:20 PM
Reviewer: Pradeep Mutalik
Owner: Tom Morse