Pathological mechanism
Donepezil modulates potassium channels
  • Dendritic Hypothesis - K+ current Show Other
  • Isolated neurons of the land snake Helix Show Other
This work was the first to show different effects of donepezil on two different types of potassium channels (I K(DR) and I K(A)) of molluscan neurons. At a low concentration (5 uM), the drug suppressed I K(DR) but augmented I K(A); at higher concentrations (10-100 uM), it reduced both current types. The ability of donepezil to reduce I K(DR) at low concentrations suggests the drug ability to prevent neurodegeneration in Alzheimer's disease. (Solntseva et al., 2005)
  • Blockage of the hyperpolarizing A-type K+ channels makes the dendrites more excitable Show Other
  • A-type K+ channel block makes dendrites more excitable Show Other
Other categories referring to Donepezil modulates potassium channels
Revisions: 4
Last Time: 7/31/2008 12:17:07 PM
Reviewer: Pradeep Mutalik
Owner: Nian Liu