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Pathological mechanism
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Synaptic integration is disrupted in an AD mouse model
  • Cortical Synaptic Integration In Vivo Is Disrupted by Amyloid-{beta} Plaques Show Other
The evoked synaptic response of neurons to transcallosal stimuli is severely impaired in cortex containing substantial plaque accumulation, with an average 2.5-fold greater rate of response failure and twofold reduction in response precision compared with age-matched nontransgenic controls. ... results show that plaques disrupt the synchrony of convergent inputs, reducing the ability of neurons to successfully integrate and propagate information. (Stern et al. 2004)
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Revisions: 5
Last Time: 11/21/2008 10:27:08 AM
Reviewer: Pradeep Mutalik
Owner: Tom Morse