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Pathological mechanism
  Data
Protofibrillar intermediates of ABeta change firing pattern of neurons.
  • Dendritic Hypothesis - K+ current Show Other
  • Neuronal excitibility: EPSPs, action potentials and depolarization Show Other
  • Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. Show Other
Protofibrils, but not (Light Molecular Weight) Abeta, produced a rapid increase in EPSPs, action potentials, and membrane depolarizations (and neurotoxicity) in cultured neurons from rat embryo brain. (Hartley et al. 1999)
  • Blockage of the hyperpolarizing A-type K+ channels makes the dendrites more excitable Show Other
  • A-type K+ channel block makes dendrites more excitable Show Other
Other categories referring to Protofibrillar intermediates of ABeta change firing pattern of neurons.
Revisions: 9
Last Time: 11/21/2008 10:31:40 AM
Reviewer: Pradeep Mutalik
Owner: Tom Morse