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10973607
In vivo synaptic transmission in young and aged amyloid precursor protein transgenic mice.
Giacchino J, Criado JR, Games D, Henriksen S
Alzheimer's disease (AD) is characterized by progressive neurodegeneration and cognitive impairment. We examined in vivo alterations in hippocampal neurotransmission in both young and aged PDAPP transgenic mice and nontransgenic littermates. We now report that in vivo abnormal neurotransmission in hippocampal circuits of PDAPP mice precedes beta deposition and neurodegeneration. These in vivo data provide the first evidence that dysfunction in hippocampal neuronal circuits may not be correlated with age-related extracellular beta plaque deposition.
876
185-90
2000
Other categories referring to 10973607
Pathological mechanism.Citation   (1)
Revisions: 1
Last Time: 9/25/2006 1:09:38 PM
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Owner: Tom Morse