|
|
|
Data
|
Pyramidal neuron coincidence detection tuned by dendritic branching pattern (Schaefer et al 2003)
|
|
|
|
|
|
|
"... We examined the relationship between dendritic arborization
and the coupling between somatic and dendritic action potential
(AP) initiation sites in layer 5 (L5) neocortical pyramidal neurons.
Coupling was defined as the relative reduction in threshold for
initiation of a dendritic calcium AP due to a coincident
back-propagating AP. Simulations based on reconstructions of
biocytin-filled cells showed that addition of oblique branches of the
main apical dendrite in close proximity to the soma (d < 140 um)
increases the coupling between the apical and axosomatic AP initiation
zones, whereas incorporation of distal branches decreases
coupling. ... We conclude that variation in dendritic arborization may
be a key determinant of variability in coupling (49+-17%; range
19-83%; n = 37) and is likely to outweigh the contribution made by
variations in active membrane properties. Thus coincidence detection
of inputs arriving from different cortical layers is strongly
regulated by differences in dendritic arborization."
|
|
|
|
|
|
|
|
|
-
Neuron or other electrically excitable cell Show
Other
|
|
|
|
|
-
Schaefer AT, Larkum ME, Sakmann B, Roth A (2003) Show
Other
|
|
|
83344
|
|
|
|
|
|
|
-
Schaefer, Andreas T [andreas.schaefer at crick.ac.uk] Show
Other
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
current
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
