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Data
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INa and IKv4.3 heterogeneity in canine LV myocytes (Flaim et al 2006)
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"The roles of sustained components of INa and IKv43 in shaping the
action potentials (AP) of myocytes isolated from the canine left
ventricle (LV) have not been studied in detail. Here we investigate
the hypothesis that these two currents can contribute substantially to
heterogeneity of early repolarization and arrhythmic
risk.... The resulting simulations illustrate ways in which KChIP2- and
Ca2+- dependent control of IKv43 can result in a sustained outward
current that can neutralize INaL in a rate- and myocyte
subtype-dependent manner. Both these currents appear to play
significant roles in modulating AP duration and rate dependence in
midmyocardial myocytes. ... By design, these models allow upward
integration into organ models or may be used as a basis for further
investigations into cellular heterogeneities." See paper for more
and details.
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Flaim SN, Giles WR, McCulloch AD (2006) Show
Other
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Flaim, Sarah [flaim at comlab.ox.ac.uk] Show
Other
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Late Na, Na/Ca exchanger, INaCa, ISERCA
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