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Data
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Subthreshold inact. of K channels modulates APs in bitufted interneurons (Korngreen et al 2005)
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... In this study we show that in bitufted interneurones
from layer 2/3 of the somatosensory cortex, the height and width of APs recorded at the
soma are sensitive to changes in the resting membrane potential, suggesting subthreshold
activity of voltage-gated conductances. Attributes of K+ currents examined in nucleated
patches revealed a fast subthreshold-inactivating K+ conductance (Kf ) and a slow
suprathreshold-inactivating K+ conductance (Ks ). Simulations of these K+ conductances,
incorporated into a Hodgkin–Huxley-type model, suggested that during a single AP or during
low frequency trains of APs, subthreshold inactivation of Kf was the primary modulator of AP
shape, whereas during trains of APs the shape was governed to a larger degree by Ks resulting
in the generation of smaller and broader APs. ... Compartmental simulation
of the back-propagating AP suggested a mechanism for the modulation of the back-propagating
AP height and width by subthreshold activation of Kf . We speculate that this signal may
modulate retrograde GABA release and consequently depression of synaptic efficacy of excitatory
input from neighbouring pyramidal neurones.
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Korngreen A, Kaiser KM, Zilberter Y (2005) Show
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Korngreen, Alon [alon.korngreen at gmail.com] Show
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