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Data
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TTX-R Na+ current effect on cell response (Herzog et al 2001)
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"Small dorsal root ganglion (DRG) neurons, which include nociceptors,
express multiple voltage-gated sodium currents. In addition to a
classical fast inactivating tetrodotoxin-sensitive (TTX-S) sodium
current, many of these cells express a TTX-resistant (TTX-R) sodium
current that activates near -70 mV and is persistent at negative
potentials. To investigate the possible contributions of this TTX-R
persistent (TTX-RP) current to neuronal excitability, we carried out
computer simulations using the Neuron program with TTX-S and -RP
currents, fit by the Hodgkin-Huxley model, that closely matched the
currents recorded from small DRG neurons. ..." See paper for more and details.
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Neuron or other electrically excitable cell Show
Other
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Herzog RI, Cummins TR, Waxman SG (2001) Show
Other
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Morse, Tom [Tom.Morse at Yale.edu] Show
Other
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tom.morse@yale.edu
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