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Data
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Markov models of SCN1A (NaV1.1) applied to abnormal gating and epilepsy (Clancy and Kass 2004)
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"Recently, some forms of idiopathic epilepsy have been causally related to
genetic mutations in neuronal ion channels. To understand disease
mechanisms, it is crucial to understand how a gene defect can disrupt
channel gating, which in turn can affect complex cellular dynamic
processes. We develop a theoretical Markovian model of the neuronal
Na+ channel NaV1.1 to explore and explain gating mechanisms underlying
cellular excitability and physiological and pathophysiological
mechanisms of abnormal neuronal excitability in the context of
epilepsy. ..."
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Clancy, Colleen E [ceclancy at ucdavis.edu] Show
Other
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tom.morse@yale.edu
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Clancy CE, Kass RS (2004) Theoretical investigation of the neuronal Na+ channel SCN1A: abnormal gating and epilepsy. Biophys J 86:2606—14
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