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AP shape and parameter constraints in optimization of compartment models (Weaver and Wearne 2006)
"... We construct an objective function that includes both time-aligned action potential shape error and errors in firing rate and firing regularity. We then implement a variant of simulated annealing that introduces a recentering algorithm to handle infeasible points outside the boundary constraints. We show how our objective function captures essential features of neuronal firing patterns, and why our boundary management technique is superior to previous approaches."
  • Neuron or other electrically excitable cell Show Other
  • Weaver, Christina [christina.weaver at fandm.edu] Show Other
tom.morse@yale.edu
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Revisions: 25
Last Time: 1/19/2014 10:07:44 AM
Reviewer: Robert A McDougal
Owner: Tom Morse - MoldelDB admin