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Data
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The role of ATP-sensitive potassium channels in a hippocampal neuron (Huang et al. 2007)
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"Hyperglycemia-related neuronal excitability and epileptic seizures
are not uncommon in clinical practice. However, their underlying
mechanism remains elusive. ATP-sensitive K(+) (K(ATP)) channels are
found in many excitable cells, including cardiac myocytes,
pancreatic beta cells, and neurons. These channels provide a link
between the electrical activity of cell membranes and cellular
metabolism. We investigated the effects of higher extracellular
glucose on hippocampal K(ATP) channel activities and neuronal
excitability. The cell-attached patch-clamp configuration on
cultured hippocampal cells and a novel multielectrode recording
system on hippocampal slices were employed. In addition, a
simulation modeling hippocampal CA3 pyramidal neurons (Pinsky-Rinzel
model) was analyzed to investigate the role of K(ATP) channels in
the firing of simulated action potentials. ..."
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Hippocampus CA3 pyramidal GLU cell Show
Other
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Neuron or other electrically excitable cell Show
Other
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Huang CW, Huang CC, Cheng JT, Tsai JJ, Wu SN (2007) Show
Other
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snwu@mail.ncku.edu.tw
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ATP-senstive potassiun current
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Dr. Chin-Wei Huang
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