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Data
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Oxytocin and VIP involvement in prolactin secretion (Egli et al. 2004,2006, Bertram et al. 2006)
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"Prolactin (PRL) is secreted from lactotrophs of the anterior
pituitary gland of rats in a unique pattern in response to
uterine cervical stimulation (CS) during mating. Surges of
PRL secretion occur in response to relief from hypothalamic
dopaminergic inhibition and stimulation by hypothalamic releasing
neurohormones. In this study, we characterized the
role of oxytocin (OT) in this system and the involvement of
vasoactive intestinal polypeptide (VIP) from the suprachiasmatic
nucleus (SCN) in controlling OT and PRL secretion of
CS rats. ... OT
measurements of serial blood samples obtained from ovariectomized
(OVX) CS rats displayed a prominent increase at
the time of the afternoon PRL peak. The injection of VIP antisense
oligonucleotides into the SCN abolished the afternoon
increase of OT and PRL in CS-OVX animals. These findings
suggest that VIP from the SCN contributes to the regulation
of OT and PRL secretion in CS rats. We propose that in CS rats
the regulatory mechanism(s) for PRL secretion comprise coordinated
action of neuroendocrine dopaminergic and OT
cells, both governed by the daily rhythm of VIP-ergic output
from the SCN. This hypothesis is illustrated with a mathematical model."
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Neuron or other electrically excitable cell Show
Other
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Egli M, Bertram R, Toporikova N, Sellix MT, Blanco W, Freeman ME (2006) Show
Other
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Bertram R, Egli M, Toporikova N, Freeman ME (2006) Show
Other
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Egli M, Bertram R, Sellix MT, Freeman ME (2004) Show
Other
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