SenseLab
Computational model
  Data
Oxytocin and VIP involvement in prolactin secretion (Egli et al. 2004,2006, Bertram et al. 2006)
"Prolactin (PRL) is secreted from lactotrophs of the anterior pituitary gland of rats in a unique pattern in response to uterine cervical stimulation (CS) during mating. Surges of PRL secretion occur in response to relief from hypothalamic dopaminergic inhibition and stimulation by hypothalamic releasing neurohormones. In this study, we characterized the role of oxytocin (OT) in this system and the involvement of vasoactive intestinal polypeptide (VIP) from the suprachiasmatic nucleus (SCN) in controlling OT and PRL secretion of CS rats. ... OT measurements of serial blood samples obtained from ovariectomized (OVX) CS rats displayed a prominent increase at the time of the afternoon PRL peak. The injection of VIP antisense oligonucleotides into the SCN abolished the afternoon increase of OT and PRL in CS-OVX animals. These findings suggest that VIP from the SCN contributes to the regulation of OT and PRL secretion in CS rats. We propose that in CS rats the regulatory mechanism(s) for PRL secretion comprise coordinated action of neuroendocrine dopaminergic and OT cells, both governed by the daily rhythm of VIP-ergic output from the SCN. This hypothesis is illustrated with a mathematical model."
  • Neuron or other electrically excitable cell Show Other
  • Egli M, Bertram R, Toporikova N, Sellix MT, Blanco W, Freeman ME (2006) Show Other
  • Bertram R, Egli M, Toporikova N, Freeman ME (2006) Show Other
  • Egli M, Bertram R, Sellix MT, Freeman ME (2004) Show Other
False
False
Other categories referring to Oxytocin and VIP involvement in prolactin secretion (Egli et al. 2004,2006, Bertram et al. 2006)
Revisions: 15
Last Time: 7/26/2015 1:33:01 PM
Reviewer: Tom Morse - MoldelDB admin
Owner: Tom Morse - MoldelDB admin