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Data
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Low dose of dopamine may stimulate prolactin secretion by increasing K currents (Tabak et al. 2006)
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".. We considered
the fast K+ currents flowing through large-conductance
BK channels and through A-type channels. We developed a
minimal lactotroph model to investigate the effects of these
two currents. Both IBK and IA could transform the electrical
pattern of activity from spiking to bursting, but through
distinct mechanisms. IBK always increased the intracellular
Ca2+ concentration, while IA could either increase or
decrease it. Thus, the stimulatory effects of DA could be
mediated by a fast K+ conductance which converts tonically
spiking cells to bursters. In addition, the study illustrates that
a heterogeneous distribution of fast K+ conductances could
cause heterogeneous lactotroph firing patterns."
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Neuron or other electrically excitable cell Show
Other
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Tabak J, Toporikova N, Freeman ME, Bertram R (2007) Show
Other
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