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Data
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Ion channel modeling with whole cell and a genetic algorithm (Gurkiewicz and Korngreen 2007)
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"... Here we show that a genetic search algorithm in combination with a gradient descent algorithm can be used to
fit whole-cell voltage-clamp data to kinetic models with a high degree of accuracy. Previously, ion channel stimulation
traces were analyzed one at a time, the results of these analyses being combined to produce a picture of channel
kinetics. Here the entire set of traces from all stimulation protocols are analysed simultaneously. The algorithm was
initially tested on simulated current traces produced by several Hodgkin-Huxley–like and Markov chain models of
voltage-gated potassium and sodium channels. ... Finally, the algorithm was used for finding the kinetic parameters of several voltage-gated
sodium and potassium channels models by matching its results to data recorded from layer 5 pyramidal neurons
of the rat cortex in the nucleated outside-out patch configuration. The minimization scheme gives electrophysiologists
a tool for reproducing and simulating voltage-gated ion channel kinetics at the cellular level."
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Ga_demo
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Korngreen, Alon [alon.korngreen at gmail.com] Show
Other
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tom.morse@yale.edu
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A Numerical Approach to Ion Channel Modelling Using Whole-Cell Voltage-Clamp Recordings and a Genetic Algorithm Gurkiewicz M, Korngreen A PLoS Computational Biology Vol. 3, No. 8, e169 doi:10.1371/journal.pcbi.0030169
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links to the original paper and model at PLoS
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