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Data
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Determinants of fast calcium dynamics in dendritic spines and dendrites (Cornelisse et al. 2007)
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"... Calcium influx time course and calcium extrusion rate were both in the same range for spines and dendrites when fitted with a dynamic multi-compartment model that included calcium binding kinetics and diffusion. In a subsequent analysis we used this model to investigate which parameters are critical determinants in spine calcium dynamics. The model confirmed the experimental findings: a higher SVR (surface-to-volume ratio) is not sufficient by itself to explain the faster rise time kinetics in spines, but only when paired with a lower buffer capacity in spines. Simulations at zero calcium-dye conditions show that calmodulin is more efficiently activated in spines, which indicates that spine morphology and buffering conditions in neocortical spines favor synaptic plasticity. ..."
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Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell Show
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Cornelisse LN, van Elburg RA, Meredith RM, Yuste R, Mansvelder HD (2007) Show
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van Elburg, Ronald A.J. [R.van.Elburg at ai.rug.nl] Show
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Calcium Dynamics
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van Elburg, Ronald A.J.
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