SenseLab
Neuronal Receptors
  Data
NA-91
True
  • Olfactory bulb main mitral GLU cell Show Other
  • Show Other
  • Both ionotropic NMDA and non-NMDA autoreceptors are activated by glutamate released from primary and secondary dendrites. In contrast to non-NMDA autoreceptors, NMDA autoreceptors are almost exclusively located on secondary dendrites and their activation generates a large and sustained self-excitation. Both intracellularly evoked and miniature NMDA-R mediated synaptic potentials are blocked by intracellular BAPTA and result from a calcium-dependent release of glutamate Show Other
  • Paired recordings in slices showed excitatory transmission mediated solely by transmitter spillover between mitral cells. Dendritic glutamate release causes self-excitation via local activation of NMDA receptors, and generates NMDA receptor-mediated responses in neighbouring cells. It is suggested that this simultaneous activation of neighbouring cells by a diffuse action of glutamate provides a mechanism for synchronizing olfactory principal cells Show Other
Other categories referring to NA-91
Trans-Recep. connectivity.Neuronal compartment receptor   (1)
Revisions: 3
Last Time: 7/17/2014 12:32:13 PM
Reviewer: System Administrator
Owner: System Administrator