Pathological Mechanisms in Alzheimer's Disease
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CompartmentCell/NeuronReceptorChannelExtracellular Pathological Agent (PA)Intracellular Pathological Agent (PA)PA ActionDrugDrug ActionStageNoteDetail
General or unspecifiedHippocampus CA1 pyramidal cellI Abeta AmyloidInhibitsEarlyViewShow
Hippocampus CA1 pyramidal cellI Calciumbeta AmyloidIncreasesNifedipineBlocksViewShow
Hippocampus CA1 pyramidal cellbeta AmyloidInhibitsEarlyViewShow
DendriteHippocampus CA1 pyramidal cellI Abeta AmyloidInhibitsEarlyViewShow
Hippocampus CA1 pyramidal cellNMDAI Calciumbeta AmyloidInhibitsViewShow
Olfactory bulb main mitral cellGabaAAluminumPotentiatesEarlyViewShow
Hippocampus CA1 pyramidal cellGlutamatebeta AmyloidInhibitsEarlyViewShow
beta AmyloidInhibitsEarlyViewShow
Cerebellum purkinje cellbeta AmyloidInducesEarlyViewShow
Brain slice preparationsAmyloid plaquesIncreasesViewShow
Golgi impregnation - Animal post-mortem brainsbeta AmyloidReducesEarlyViewShow
Apical dendriteNeocortex V1 pyramidal corticothalamic L6 cellbeta AmyloidReducesEarlyViewShow
Hippocampus CA1 pyramidal cellI Sodiumprotein kinase CInhibitsEarlyViewShow
Distal apical dendriteGolgi impregnation - Animal post-mortem brains / Neocortex V1 pyramidal corticothalamic L6 cellNerve Growth Factor (NGF)IncreasesViewShow
SomaHippocampus CA1 pyramidal cellI Abeta AmyloidInhibitsEarlyViewShow
Olfactory bulb main mitral cellGabaAAluminumPotentiatesEarlyViewShow
AMPAbeta AmyloidInhibitsEarlyViewShow
I L high thresholdbeta AmyloidReducesVerapamilBlocksEarlyViewShow
I Potassiumbeta AmyloidModulatesEarlyViewShow
OocyteNicotinicCholinergic Receptorsbeta AmyloidInhibitsEarlyViewShow
beta AmyloidIs neurotoxicEarlyViewShow
SH-SY-5Y human neuroblastoma cellsI L high thresholdMAP KinaseInducesOkadaic AcidIncreasesViewShow
I L high thresholdBeta-amyloid (1-42)Tau proteinIncreasesCalpain Inhibitor IP35 Antisense OligonucleotidesVerapamilBlocksViewShow
Cultured cortical neuronsI L high thresholdPresenilin-1ReducesViewShow
beta AmyloidInhibitsEarlyViewShow
Isolated neurons of the land snake HelixI KDonepezilModulatesViewShow
Beta amyloid plaquesInhibitsViewShow
Cultured cortical neuronsProtofibrillar AbetaIncreasesViewShow
Cerebellum interneuron granule cellI Abeta Amyloid (1-40)Increasesbrefeldin AcycloheximideBlocksViewShow
beta AmyloidInhibitsEarlyViewShow
beta AmyloidInhibitsEarlyViewShow
Hippocampus CA1 pyramidal cellNicotinicbeta AmyloidInhibitsEarlyViewShow
Brain slice preparationsbeta AmyloidInhibitsNicotineReversesEarlyViewShow
BDNF (Brain-derived neurotrophic factor)Cytoskeleton-associated protein (Arc)Is Required ForEarlyViewShow
Brain slice preparationsNicotinicNicotinePotentiatesLateViewShow
Neurofibrillary tangles (NFT)Is Correlated withLateViewShow
Human Post-mortem StudyDrebrinIs Correlated withEarlyViewShow
Brain slice preparations / Hippocampus CA1 pyramidal cellbeta AmyloidReducesRolipramBlocksEarlyViewShow
Human Post-mortem Study / Dentate gyrus granule cellApolipoprotein E4 (Apo E4)Is Inversely Correlated withEarlyViewShow
Beta-amyloid (1-42)Increasesalpha7 nicotinic receptor antagonistsBlocksViewShow
Brain slice preparationsMuscarinicI L high thresholdbeta AmyloidReducesAtropineCalcicludinePirenzepineBlocksViewShow
Brain slice preparationsNicotinicGalantamineReducesMecamylamineSulpirideOpposesLateViewShow
NicotineReducesLateViewShow
Brain slice preparationsCholinergic ReceptorsNicotinicbeta AmyloidAntagonizesAcetyl CholineCholineNicotineOpposesEarlyViewShow
Brain slice preparationsCholinergic ReceptorsNicotinicDihydro-beta-erythroidine (DHbetaE)InducesClozapineReversesEarlyViewShow
Glutamatebeta AmyloidReducesalpha7 nicotinic receptor antagonistsNMDA receptor blockersBlocksEarlyViewShow
beta AmyloidInhibitsNicotineProtectsViewShow
Golgi impregnation - Animal post-mortem brainsOral docosahexanoic acid (DHA)IncreasesCholineUridineIncreasesViewShow
Brain slice preparationsI Sodiumbeta AmyloidEarlyViewShow
Behavioral studyAdrenergicBetabeta AmyloidCL316243ReversesEarlyViewShow
Human Post-mortem Studybeta AmyloidInducesEarlyViewShow
NMDAAbeta-derived diffusible ligands (ADDLs)InducesEarlyViewShow
Brain slice preparationsbeta AmyloidTNFalphaInhibitsEarlyViewShow
Brain slice preparations / Hippocampus CA3 pyramidal cellBACE1 (beta-secretase)Is Required ForCalcium (extracellular)ReversesEarlyViewShow
beta AmyloidInducesHistidine-associating CompoundsBlocksEarlyViewShow