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Pathological Mechanisms in Alzheimer's Disease

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Compartment Cell/Neuron Receptor Channel Extracellular Pathological Agent (PA) Intracellular Pathological Agent (PA) PA Action Drug Drug Action Stage Note Detail
General or unspecified Hippocampus CA1 pyramidal GLU cell I A beta Amyloid Inhibits Early View Show
Hippocampus CA1 pyramidal GLU cell I L high threshold beta Amyloid (25-35) Increases Nifedipine Blocks View Show
Hippocampus CA1 pyramidal GLU cell I Calcium beta Amyloid Increases Nifedipine Blocks View Show
Hippocampus CA1 pyramidal GLU cell beta Amyloid Inhibits Early View Show
Dendrite Hippocampus CA1 pyramidal GLU cell I A beta Amyloid Inhibits Early View Show
Hippocampus CA1 pyramidal GLU cell NMDA I Calcium beta Amyloid Inhibits View Show
Olfactory bulb main mitral GLU cell GabaA Aluminum Potentiates Early View Show
Hippocampus CA1 pyramidal GLU cell Glutamate beta Amyloid Inhibits Early View Show
beta Amyloid Inhibits Early View Show
Cerebellum Purkinje GABA cell beta Amyloid Induces Early View Show
Brain slice preparations Amyloid plaques Increases View Show
beta Amyloid p-21 activated kinase (PAK) Early View Show
Golgi impregnation - Animal post-mortem brains beta Amyloid Reduces Early View Show
Apical dendrite Neocortex L5/6 pyramidal GLU cell beta Amyloid Reduces Early View Show
Hippocampus CA1 pyramidal GLU cell I Sodium protein kinase C Inhibits Early View Show
Distal apical dendrite Golgi impregnation - Animal post-mortem brains/Neocortex L5/6 pyramidal GLU cell Nerve Growth Factor (NGF) Increases View Show
Soma Hippocampus CA1 pyramidal GLU cell I A beta Amyloid Inhibits Early View Show
Olfactory bulb main mitral GLU cell GabaA Aluminum Potentiates Early View Show
AMPA beta Amyloid Inhibits Early View Show
Oocyte I L high threshold beta Amyloid MAP Kinase Early View Show
I L high threshold beta Amyloid Reduces Verapamil Blocks Early View Show
I L high threshold beta Amyloid (25-35) Potentiates Nimodipine Decreases Early View Show
I Potassium beta Amyloid Modulates Early View Show
NMDA I L high threshold beta Amyloid Inhibits Verapamil Early View Show
Oocyte Nicotinic Cholinergic Receptors beta Amyloid Inhibits Early View Show
beta Amyloid Is neurotoxic Early View Show
beta Amyloid Inhibits Clonidine THA Early View Show
I L high threshold Early View Show
SH-SY-5Y human neuroblastoma cells I L high threshold MAP Kinase Induces Okadaic Acid Increases View Show
I L high threshold Beta-amyloid (1-42) Tau protein Increases Calpain Inhibitor I P35 Antisense Oligonucleotides Verapamil Blocks View Show
Cultured cortical neurons I L high threshold Presenilin-1 Reduces View Show
beta Amyloid Inhibits Early View Show
Cultured septal neurons beta Amyloid Is neurotoxic Donepezil Reduces View Show
Isolated neurons of the land snake Helix I K Donepezil Modulates View Show
Beta amyloid plaques Inhibits View Show
Cultured cortical neurons Protofibrillar Abeta Increases View Show
Cerebellum interneuron granule GLU cell I A beta Amyloid (1-40) Increases brefeldin A cycloheximide Blocks View Show
beta Amyloid Inhibits Early View Show
beta Amyloid Inhibits Early View Show
Hippocampus CA1 pyramidal GLU cell Nicotinic beta Amyloid Inhibits Early View Show
NMDA Serum Mg+2 Is Correlated with Early View Show
Brain slice preparations beta Amyloid Inhibits Nicotine Reverses Early View Show
BDNF (Brain-derived neurotrophic factor) Cytoskeleton-associated protein (Arc) Is Required For Early View Show
Brain slice preparations Nicotinic Nicotine Potentiates Late View Show
beta Amyloid p-21 activated kinase (PAK) Inhibits Late View Show
beta Amyloid p-21 activated kinase (PAK) Disrupts Late View Show
NMDA Early View Show
Neurofibrillary tangles (NFT) Is Correlated with Late View Show
Human Post-mortem Study/Hippocampus CA1 pyramidal GLU cell Is Correlated with Early View Show
Hippocampus CA1 pyramidal GLU cell Drebrin Is Correlated with Early View Show
Human Post-mortem Study Drebrin Is Correlated with Early View Show
Brain slice preparations/Hippocampus CA1 pyramidal GLU cell beta Amyloid Reduces Rolipram Blocks Early View Show
Drebrin Is Inversely Correlated with View Show
Human Post-mortem Study/Dentate gyrus granule GLU cell Apolipoprotein E4 (Apo E4) Is Inversely Correlated with Early View Show
BC-Phosphatidylserine (BC-PS) Reduces Late View Show
Beta-amyloid (1-42) Increases alpha7 nicotinic receptor antagonists Blocks View Show
Brain slice preparations Muscarinic I L high threshold beta Amyloid Reduces Atropine Calcicludine Pirenzepine Blocks View Show
Brain slice preparations Nicotinic Galantamine Reduces Mecamylamine Sulpiride Opposes Late View Show
ACh Esterase inhibitors Reduces Late View Show
Nicotine Reduces Late View Show
Nicotine Increases Mecamylamine Decreases Late View Show
beta Amyloid Copper Increases Nicotine Opposes Late View Show
NMDA Reduces Late View Show
Brain slice preparations Nicotine Copper Reduces Late View Show
Brain slice preparations Cholinergic Receptors Nicotinic beta Amyloid Antagonizes Acetyl Choline Choline Nicotine Opposes Early View Show
Brain slice preparations Cholinergic Receptors Nicotinic Dihydro-beta-erythroidine (DHbetaE) Induces Clozapine Reverses Early View Show
Cultured cortical neurons beta Amyloid Increases Late View Show
Glutamate beta Amyloid Reduces alpha7 nicotinic receptor antagonists NMDA receptor blockers Blocks Early View Show
beta Amyloid Inhibits Nicotine Protects View Show
Golgi impregnation - Animal post-mortem brains Oral docosahexanoic acid (DHA) Increases Choline Uridine Increases View Show
Human Post-mortem Study beta Amyloid Tau protein View Show
Brain slice preparations I Sodium beta Amyloid Early View Show
Behavioral study Adrenergic Beta beta Amyloid CL316243 Reverses Early View Show
Human Post-mortem Study beta Amyloid Induces Early View Show
NMDA Abeta-derived diffusible ligands (ADDLs) Induces Early View Show
Cultured cortical neurons beta Amyloid Induces Gingkolides Protects Early View Show
Brain slice preparations beta Amyloid TNFalpha Inhibits Early View Show
beta Amyloid Rho kinases (ROCK1/2) Disrupts Early View Show
Is Correlated with Early View Show
Brain slice preparations/Hippocampus CA3 pyramidal GLU cell BACE1 (beta-secretase) Is Required For Calcium (extracellular) Reverses Early View Show
beta Amyloid Induces Histidine-associating Compounds Blocks Early View Show