| || Models ||Description|
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
||" ... We investigated oscillatory control using a multiscale computer model of hippocampal CA3, where each cell class
(pyramidal, basket, and oriens-lacunosum moleculare cells), contained type-appropriate isoforms of Ih.
demonstrated that modulation of pyramidal and basket Ih allows tuning theta and gamma oscillation frequency and
amplitude. Pyramidal Ih also controlled cross-frequency coupling (CFC) and allowed shifting gamma generation towards
particular phases of the theta cycle, effected via Ih’s ability to set pyramidal excitability. ..."
Leech Heart (HE) Motor Neuron conductances contributions to NN activity (Lamb & Calabrese 2013)
To explore the relationship between conductances,
and in particular how they influence the activity of motor neurons in
the well characterized leech heartbeat system, we developed a new
multi-compartmental Hodgkin-Huxley style leech heart motor neuron
To do so, we evolved a population of model instances, which
differed in the density of specific conductances, capable of achieving
specific output activity targets given an associated input pattern.
We found that the strengths of many conductances,
including those with differing dynamics, had strong partial
correlations and that these relationships appeared to be linked by
their influence on heart motor neuron activity.
Conductances that had
positive correlations opposed one another and had the opposite effects
on activity metrics when perturbed whereas conductances that had
negative correlations could compensate for one another and had similar
effects on activity metrics.
Model of arrhythmias in a cardiac cells network (Casaleggio et al. 2014)
||" ... Here we explore the possible processes leading to the occasional onset and termination of the (usually) non-fatal arrhythmias widely observed in the heart.
Using a computational model of a two-dimensional network of cardiac cells, we tested the hypothesis that an ischemia alters the properties of the gap junctions inside the ischemic area.
In conclusion, our model strongly supports the hypothesis that non-fatal arrhythmias can develop from post-ischemic alteration of the electrical connectivity in a relatively small area of the cardiac cell network, and suggests experimentally testable predictions on their possible treatments."