| || Models ||Description|
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
||"Neuronal persistent activity has been primarily assessed in terms of electrical mechanisms, without attention to the complex array of molecular events that also control cell excitability. We developed a multiscale neocortical model proceeding from the molecular to the network level to assess the contributions of calcium regulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in providing additional and complementary support of continuing activation in the network. ..."
Olfactory bulb network: neurogenetic restructuring and odor decorrelation (Chow et al. 2012)
||Adult neurogenesis in the olfactory bulb has been shown experimentally
to contribute to perceptual learning. Using a computational network
model we show that fundamental aspects of the adult neurogenesis
observed in the olfactory bulb -- the persistent addition of new
inhibitory granule cells to the network, their activity-dependent
survival, and the reciprocal character of their synapses with the
principal mitral cells -- are sufficient to restructure the network
and to alter its encoding of odor stimuli adaptively so as to reduce
the correlations between the bulbar representations of similar
stimuli. The model captures the experimentally observed
role of neurogenesis in perceptual learning and the enhanced response
of young granule cells to novel stimuli. Moreover, it makes specific
predictions for the type of odor enrichment that should be effective
in enhancing the ability of animals to discriminate similar odor
mixtures. NSF grant DMS-0719944.
Synchronization by D4 dopamine receptor-mediated phospholipid methylation (Kuznetsova, Deth 2008)
||"We describe a new molecular mechanism of
dopamine-induced membrane protein modulation that
can tune neuronal oscillation frequency to attention related
gamma rhythm. This mechanism is based on
the unique ability of D4 dopamine receptors (D4R)
to carry out phospholipid methylation (PLM) that
may affect the kinetics of ion channels.
We show that by deceasing the inertia of the delayed rectifier potassium channel, a transition to 40 Hz oscillations can be achieved. ..."