STDP depends on dendritic synapse location (Letzkus et al. 2006)

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Accession:108459
This model was published in Letzkus, Kampa & Stuart (2006) J Neurosci 26(41):10420-9. The simulation creates several plots showing voltage and NMDA current and conductance changes at different apical dendritic locations in layer 5 pyramidal neurons during STDP induction protocols. Created by B. Kampa (2006).
Reference:
1 . Letzkus JJ, Kampa BM, Stuart GJ (2006) Learning rules for spike timing-dependent plasticity depend on dendritic synapse location. J Neurosci 26:10420-9 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex V1 L6 pyramidal corticothalamic GLU cell;
Channel(s): I L high threshold; I T low threshold; I A; I M; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s): NMDA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Bursting; Active Dendrites; Synaptic Plasticity; Long-term Synaptic Plasticity; Action Potentials; STDP; Calcium dynamics;
Implementer(s): Kampa, Bjorn M [Bjoern.Kampa at anu.edu.au];
Search NeuronDB for information about:  Neocortex V1 L6 pyramidal corticothalamic GLU cell; NMDA; I L high threshold; I T low threshold; I A; I M; I K,Ca; I Sodium; I Calcium; I Potassium; Glutamate;
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LetzkusEtAl2006
mod
ca.mod *
cad.mod
epsp.mod *
h.mod
it2.mod *
kaprox.mod *
kca.mod *
km.mod *
kv.mod *
na.mod *
NMDA_Mg.mod
release_BMK.mod *
                            
TITLE Ih-current

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
     (mM) = (milli/liter)

}

INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}

PARAMETER {
	dt (ms)
	v (mV)
     ehd=-45  			(mV)
	ghdbar=0.00015 		(S/cm2)	:density on dendrite assuming 150pA current and 150mV driving force (=200pS/um2)
	gamma_ih	:not used
	seed		:not used
}


NEURON {
	SUFFIX ih
	NONSPECIFIC_CURRENT Iqq
	RANGE Iqq,ghdbar
}

STATE {
	qq
}

ASSIGNED {
	Iqq (mA/cm2)
}

INITIAL {
	qq=alpha(v)/(beta(v)+alpha(v))
}

BREAKPOINT {
	SOLVE state METHOD cnexp
	Iqq = ghdbar*qq*(v-ehd)
}

FUNCTION alpha(v(mV)) {
	alpha = 0.001*6.43*(v+154.9)/(exp((v+154.9)/11.9)-1)			:parameters are estimated by direct fitting of HH model to activation time constants and voltage actication curve recorded at  34C by M. Kole
}

FUNCTION beta(v(mV)) {
	beta = 0.001*193*exp(v/33.1)			
}

DERIVATIVE state {     : exact when v held constant; integrates over dt step
	qq' = (1-qq)*alpha(v) - qq*beta(v)
}