Space clamp problems in neurons with voltage-gated conductances (Bar-Yehuda and Korngreen 2008)

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Accession:110560
" ... using numerical simulations, we show that the distortions of voltage-gated K+ and Ca2+ currents are substantial even in neurons with short dendrites. The simulations also demonstrate that passive cable theory cannot be used to justify voltage-clamping of neurons, due to significant shunting to the reversal potential of the voltage-gated conductance during channel activation. ... "
Reference:
1 . Bar-Yehuda D, Korngreen A (2008) Space-clamp problems when voltage clamping neurons expressing voltage-gated conductances. J Neurophysiol 99:1127-36 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell;
Channel(s): I K; I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Influence of Dendritic Geometry; Detailed Neuronal Models;
Implementer(s): Korngreen, Alon [alon.korngreen at gmail.com];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; I K; I Calcium;
/
SpaceClampDemo
cells
A0606.hoc
C050800E2.hoc
C230998A-I3.hoc
j7_L4stellate.hoc *
                            
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