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Kinetic properties of voltage gated Na channel (Nayak and Sikdar 2007)
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Here we illustrate novel non-linear properties of voltage gated Na+ channel induced by sustained membrane depolarization. In cell-attached patch clamp recordings of rNav1.2 channels expressed in CHO cells, we found complex non-linear changes in the molecular kinetic properties, including channel dwell times and unitary conductance of single Na+ channels that were dependent on the extent of conditioning membrane depolarization. A “molecular memory” phenomenon arises at longer depolarization characterized by clusters of dwell time events and strong autocorrelation in dwell times. Hidden Markov Modeling (HMM) ... suggested a possible explanation to the memory phenomenon. See paper for more and details.
Nayak TK, Sikdar SK (2007) Time-dependent molecular memory in single voltage-gated sodium channel.
J Membr Biol
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Ion Channel Kinetics;
Nayak, Tapan Kumar [tapan at mbu.iisc.ernet.in];
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