Kinetic properties of voltage gated Na channel (Nayak and Sikdar 2007)

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Here we illustrate novel non-linear properties of voltage gated Na+ channel induced by sustained membrane depolarization. In cell-attached patch clamp recordings of rNav1.2 channels expressed in CHO cells, we found complex non-linear changes in the molecular kinetic properties, including channel dwell times and unitary conductance of single Na+ channels that were dependent on the extent of conditioning membrane depolarization. A “molecular memory” phenomenon arises at longer depolarization characterized by clusters of dwell time events and strong autocorrelation in dwell times. Hidden Markov Modeling (HMM) ... suggested a possible explanation to the memory phenomenon. See paper for more and details.
1 . Nayak TK, Sikdar SK (2007) Time-dependent molecular memory in single voltage-gated sodium channel. J Membr Biol 219:19-36 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I Sodium;
Gap Junctions:
Simulation Environment: Yale HMM;
Model Concept(s): Ion Channel Kinetics; Epilepsy; Markov-type model;
Implementer(s): Nayak, Tapan Kumar [tapan at];
Search NeuronDB for information about:  I Sodium;
 0        1.52E-13       0.8
 0        8.84E-14       0.1
-1.1E-12  1.99E-13       0.0
 0        1.39E-13       0.1

NoiseControl 1
StandardDeviation 2.05E-13
ARCoefficients	5.76E-001  -5.47E-001  4.31E-001  -2.02E-001

-1200	1000   0      200 
 150   -1550   1200   200	
 0      200   -400    200
 0      0      0      0

NumberOfSweeps	  100
PointsInSweeps	 20000
SamplingInterval 0.00004