CA1 pyramidal neuron: functional significance of axonal Kv7 channels (Shah et al. 2008)

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Accession:112546
The model used in this paper confirmed the experimental findings suggesting that axonal Kv7 channels are critically and uniquely required for determining the inherent spontaneous firing of hippocampal CA1 pyramids, independently of alterations in synaptic activity. The model predicts that the axonal Kv7 density could be 3-5 times that at the soma.
Reference:
1 . Shah MM, Migliore M, Valencia I, Cooper EC, Brown DA (2008) Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons. Proc Natl Acad Sci U S A 105:7869-74 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Axon; Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I Na,t; I T low threshold; I A; I K; I M; I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Detailed Neuronal Models; Axonal Action Potentials; Action Potentials;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; I Na,t; I T low threshold; I A; I K; I M; I Calcium;
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km
readme.html
cacumm.mod *
cagk.mod
cal2.mod
can2.mod
cat.mod *
h.mod *
kadist.mod *
KahpM95.mod *
kaprox.mod *
kdrca1.mod *
km.mod *
na3n.mod *
naxn.mod *
fig4a.hoc
fixnseg.hoc *
geo9068802.hoc *
mosinit.hoc *
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:Migliore file Modify by Maciej Lazarewicz (mailto:mlazarew@gmu.edu) May/16/2001

TITLE Borg-Graham type generic K-AHP channel

NEURON {
	SUFFIX KahpM95
	USEION k READ ek WRITE ik
        USEION ca READ cai
        RANGE  gbar,ik, gkahp
        GLOBAL inf,tau
}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
}

PARAMETER {
	celsius = 6.3	(degC)
	gbar	= .003 	(mho/cm2)
        n	= 4
        cai	= 50.e-6 (mM)
        a0	= 1e8 (/ms-mM-mM-mM-mM)		:b0/(20e-4^4)
        b0	= .5e-2  (/ms)			:0.5/(0.100e3)
        v       	 (mV)
        ek      	 (mV)
	q10=3
}

STATE {	w }

ASSIGNED {
	ik 		(mA/cm2)
        gkahp  		(mho/cm2)
        inf
        tau
}

BREAKPOINT {
	SOLVE state METHOD cnexp
	gkahp = gbar*w
	ik = gkahp*(v-ek)
}

INITIAL {
	rate(cai)
	w=inf
}

FUNCTION alp(cai (mM)) {
  alp = a0*cai^n
}

DERIVATIVE state {     : exact when v held constant; integrates over dt step
        rate(cai)
        w' = (inf - w)/tau
}

PROCEDURE rate(cai (mM)) { :callable from hoc
        LOCAL a,qt
        qt=q10^((celsius-24)/10)
        a = alp(cai)
        tau = 1/(qt*(a + b0))
        inf = a*tau*qt
}