Computer simulations of neuron-glia interactions mediated by ion flux (Somjen et al. 2008)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:113446
"... To examine the effect of glial K+ uptake, we used a model neuron equipped with Na+, K+, Ca2+ and Cl− conductances, ion pumps and ion exchangers, surrounded by interstitial space and glia. The glial membrane was either “passive”, incorporating only leak channels and an ion exchange pump, or it had rectifying K+ channels. We computed ion fluxes, concentration changes and osmotic volume changes. ... We conclude that voltage gated K+ currents can boost the effectiveness of the glial “potassium buffer” and that this buffer function is important even at moderate or low levels of excitation, but especially so in pathological states."
Reference:
1 . Somjen GG, Kager H, Wadman WJ (2008) Computer simulations of neuron-glia interactions mediated by ion flux. J Comput Neurosci 25:349-65 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Electrogenic pump; Glia;
Brain Region(s)/Organism:
Cell Type(s): Astrocyte;
Channel(s): I Na,p; I Na,t; I T low threshold; I A; I K; I K,Ca; Na/Ca exchanger; Na/K pump;
Gap Junctions:
Receptor(s): NMDA;
Gene(s):
Transmitter(s): Ions;
Simulation Environment: NEURON;
Model Concept(s): Epilepsy; Calcium dynamics; Sodium pump;
Implementer(s):
Search NeuronDB for information about:  NMDA; I Na,p; I Na,t; I T low threshold; I A; I K; I K,Ca; Na/Ca exchanger; Na/K pump; Ions;
NEURON {
	SUFFIX getconc
	USEION na WRITE nai, nao
	USEION  k WRITE  ki,  ko
	USEION cl WRITE cli, clo
	USEION  a WRITE  ai,  ao
	POINTER naig, naog, kig, kog, clig, clog, aig, aog
}

ASSIGNED {
	naig naog kig kog clig clog aig aog
}

STATE { nai nao ki ko cli clo ai ao }

BREAKPOINT {
	:at_time(t) {
	  nai=naig nao=naog ki=kig ko=kog
	  cli=clig clo=clog ai=aig ao=aog
	:}

}
INITIAL {
	at_time(t) {
	  nai=naig nao=naog ki=kig ko=kog
	  cli=clig clo=clog ai=aig ao=aog
	}
}