An allosteric kinetics of NMDARs in STDP (Urakubo et al. 2008)


Help downloading and running models
Accession:114365
"... We developed a detailed biophysical model of STDP and found that the model required spike timing-dependent distinct suppression of NMDARs by Ca2+-calmodulin. This led us to predict an allosteric kinetics of NMDARs: a slow and rapid suppression of NMDARs by Ca2+-calmodulin with prespiking -> postspiking and postspiking -> prespiking, respectively. We found that the allosteric kinetics, but not the conventional kinetics, is consistent with specific features of amplitudes and peak time of NMDAR-mediated EPSPs in experiments. ..." See paper for more and details.
Reference:
1 . Urakubo H, Honda M, Froemke RC, Kuroda S (2008) Requirement of an allosteric kinetics of NMDA receptors for spike timing-dependent plasticity. J Neurosci 28:3310-23 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I Na,t; I A; I K; I Calcium;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS (web link to model);
Model Concept(s): Ion Channel Kinetics; Signaling pathways; STDP;
Implementer(s):
Search NeuronDB for information about:  AMPA; NMDA; I Na,t; I A; I K; I Calcium;
(located via links below)