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Tag Trigger Consolidation (Clopath and Ziegler et al. 2008)
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This model simulates different phases of LTP/D, i.e. the induction or early phase, the setting of synaptic tags, a trigger process for protein synthesis, and a slow transition leading to synaptic consolidation namely the late phase of synaptic plasticity. The model explains a large body of experimental data on synaptic tagging and capture, cross-tagging, and the late phases of LTP and LTD. Moreover, the model accounts for the dependence of LTP and LTD induction on voltage and presynaptic stimulation frequency.
Clopath C, Ziegler L, Vasilaki E, Büsing L, Gerstner W (2008) Tag-trigger-consolidation: a model of early and late long-term-potentiation and depression.
PLoS Comput Biol
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Neuron or other electrically excitable cell;
Hippocampus CA1 pyramidal GLU cell;
Abstract integrate-and-fire adaptive exponential (AdEx) neuron;
Long-term Synaptic Plasticity;
Ziegler, Lorric ;
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Hippocampus CA1 pyramidal GLU cell
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