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Mechanisms of very fast oscillations in axon networks coupled by gap junctions (Munro, Borgers 2010)
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Model Information
Model File
Accession:
120907
Axons connected by gap junctions can produce very fast oscillations (VFOs, > 80 Hz) when stimulated randomly at a low rate. The models here explore the mechanisms of VFOs that can be seen in an axonal plexus, (Munro & Borgers, 2009): a large network model of an axonal plexus, small network models of axons connected by gap junctions, and an implementation of the model underlying figure 12 in Traub et al. (1999) . The large network model consists of 3,072 5-compartment axons connected in a random network. The 5-compartment axons are the 5 axonal compartments from the CA3 pyramidal cell model in Traub et al. (1994) with a fixed somatic voltage. The random network has the same parameters as the random network in Traub et al. (1999), and axons are stimulated randomly via a Poisson process with a rate of 2/s/axon. The small network models simulate waves propagating through small networks of axons connected by gap junctions to study how local connectivity affects the refractory period.
Reference:
1 .
Munro E, BĂ¶rgers C (2010) Mechanisms of very fast oscillations in networks of axons coupled by gap junctions.
J Comput Neurosci
28
:539-55
[
PubMed
]
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Model Information
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Model Type:
Realistic Network;
Neuron or other electrically excitable cell;
Axon;
Brain Region(s)/Organism:
Hippocampus;
Cell Type(s):
Hippocampus CA3 pyramidal GLU cell;
Channel(s):
I Na,t;
I K;
Gap Junctions:
Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
C or C++ program;
Model Concept(s):
Oscillations;
Detailed Neuronal Models;
Axonal Action Potentials;
Epilepsy;
Conduction failure;
Implementer(s):
Munro, Erin [ecmun at math.bu.edu];
Search NeuronDB
for information about:
Hippocampus CA3 pyramidal GLU cell
;
I Na,t
;
I K
;
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Munro_Borgers_2009
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