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CA1 pyramidal neuron to study INaP properties and repetitive firing (Uebachs et al. 2010)
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A model of a CA1 pyramidal neuron containing a biophysically realistic morphology and 15 distributed voltage and Ca2+-dependent conductances. Repetitive firing is modulated by maximal conductance and the voltage dependence of the persistent Na+ current (INaP).
Uebachs M, Opitz T, Royeck M, Dickhof G, Horstmann MT, Isom LL, Beck H (2010) Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents.
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Neuron or other electrically excitable cell;
Hippocampus CA1 pyramidal GLU cell;
ATP-senstive potassium current;
Detailed Neuronal Models;
Horstmann, Marie-Therese [mhorstma at uni-bonn.de];
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Hippocampus CA1 pyramidal GLU cell
ATP-senstive potassium current
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